• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Prostaglandin E inhibits the production of human interleukin 2.前列腺素E抑制人白细胞介素2的产生。
J Exp Med. 1982 Mar 1;155(3):943-8. doi: 10.1084/jem.155.3.943.
2
The effects of prostaglandins on extrarenal erythropoietin production.前列腺素对肾外促红细胞生成素产生的影响。
Proc Soc Exp Biol Med. 1982 Jun;170(2):231-6. doi: 10.3181/00379727-170-41424.
3
In vitro inhibition of interleukin-2 production by peripheral blood lymphocytes from stage III melanoma patients by prostaglandin E2: enhancement of lymphocyte proliferation by exogenous interleukin-2 plus indomethacin.前列腺素E2对III期黑色素瘤患者外周血淋巴细胞白细胞介素-2产生的体外抑制作用：外源性白细胞介素-2加吲哚美辛对淋巴细胞增殖的增强作用。
J Biol Response Mod. 1986 Feb;5(1):12-9.
4
Prostaglandins as endogenous mediators of interleukin 1 production.前列腺素作为白细胞介素1产生的内源性介质。
J Immunol. 1986 Jan;136(1):186-92.
5
Prostaglandin regulation of macrophage function: effect of endogenous and exogenous prostaglandins.前列腺素对巨噬细胞功能的调节：内源性和外源性前列腺素的作用
Cell Immunol. 1982 Dec;74(2):234-42. doi: 10.1016/0008-8749(82)90024-7.
6
The production of prostaglandin and the regulation of cell division in neonate rat primary mixed glial cultures.新生大鼠原代混合神经胶质细胞培养中前列腺素的产生及细胞分裂的调控
J Neuroimmunol. 1986 Jun;11(4):277-85. doi: 10.1016/0165-5728(86)90081-0.
7
Effect of prostaglandins on polymorphonuclear leukocyte motility.
Immunopharmacology. 1983 Oct;6(3):167-75. doi: 10.1016/0162-3109(83)90018-8.
8
Effect of prostaglandin on urethral resistance and micturition.
Urol Res. 1983;11(1):19-22. doi: 10.1007/BF00272704.
9
Retinoic acid enhances the initiation of DNA synthesis stimulated by prostaglandin F2 alpha in Swiss 3T3 cells.维甲酸增强前列腺素F2α刺激瑞士3T3细胞中DNA合成的起始。
Cell Biol Int Rep. 1982 Oct;6(10):961-7. doi: 10.1016/0309-1651(82)90008-x.
10
In vivo fertilization of rabbit oocytes exposed to continuous intrauterine administration of prostaglandin E2, prostaglandin F2 alpha, and indomethacin.对持续子宫内给予前列腺素E2、前列腺素F2α和吲哚美辛的兔卵母细胞进行体内受精。
Adv Prostaglandin Thromboxane Leukot Res. 1987;17B:1122-4.

引用本文的文献

1
Harnessing prostaglandin E signaling to ameliorate autoimmunity.利用前列腺素 E 信号转导来改善自身免疫。
Trends Immunol. 2023 Mar;44(3):162-171. doi: 10.1016/j.it.2023.01.004. Epub 2023 Jan 25.
2
Critical role of kinase activity of hematopoietic progenitor kinase 1 in anti-tumor immune surveillance.造血祖细胞激酶 1 的激酶活性在抗肿瘤免疫监视中的关键作用。
PLoS One. 2019 Mar 26;14(3):e0212670. doi: 10.1371/journal.pone.0212670. eCollection 2019.
3
Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production.TLR7和TLR9激动剂的不同佐剂活性与一氧化氮和前列腺素E2的产生呈负相关。
PLoS One. 2015 Apr 13;10(4):e0123165. doi: 10.1371/journal.pone.0123165. eCollection 2015.
4
The Future of Xenotransplantation.异种移植的未来。
Ann Surg. 1992 Oct 1;216(4):3-10.
5
Food components and the immune system: from tonic agents to allergens.食物成分与免疫系统：从补品到过敏原。
Front Immunol. 2013 May 17;4:102. doi: 10.3389/fimmu.2013.00102. eCollection 2013.
6
TGF-beta1 on osteoimmunology and the bone component cells.TGF-β1 与骨免疫学及骨细胞成分。
Cell Biosci. 2013 Jan 15;3(1):4. doi: 10.1186/2045-3701-3-4.
7
Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response.造血祖细胞激酶 1 是前列腺素 E2 介导的抗肿瘤免疫反应抑制的关键组成部分。
Cancer Immunol Immunother. 2010 Mar;59(3):419-29. doi: 10.1007/s00262-009-0761-0. Epub 2009 Sep 29.
8
Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC).乙酰水杨酸在抗体依赖性细胞细胞毒性 (ADCC) 中细胞因子刺激巨噬细胞中的作用。
Mediators Inflamm. 1994;3(6):419-24. doi: 10.1155/S0962935194000591.
9
Unsaturated fatty acids suppress interleukin-2 production and transferrin receptor expression by concanavalin A-stimulated rat Iymphocytes.不饱和脂肪酸通过 ConA 刺激的大鼠淋巴细胞抑制白细胞介素-2 的产生和转铁蛋白受体的表达。
Mediators Inflamm. 1992;1(2):107-12. doi: 10.1155/S0962935192000188.
10
Prostaglandin E1 (PGE1) attenuates vasoconstriction induced by PGE2, PGD2 and phorbol myristate acetate in the perfused rat liver.前列腺素E1（PGE1）可减弱灌注大鼠肝脏中由前列腺素E2（PGE2）、前列腺素D2（PGD2）和佛波醇肉豆蔻酸酯乙酸酯诱导的血管收缩。
J Anesth. 1993 Jan;7(1):56-65. doi: 10.1007/s0054030070056.

本文引用的文献

1
Regulation of the immune response by prostaglandins.前列腺素对免疫反应的调节
Clin Immunol Immunopathol. 1980 Jan;15(1):106-22. doi: 10.1016/0090-1229(80)90024-0.
2
Prostaglandin inhibition of T-cell proliferation is mediated at two levels.前列腺素对T细胞增殖的抑制作用在两个层面上介导。
Cell Immunol. 1981 Jun;61(1):52-61. doi: 10.1016/0008-8749(81)90353-1.
3
Two distinct factors are required for induction of T-cell growth.诱导T细胞生长需要两个不同的因素。
Nature. 1980 Feb 14;283(5748):664-6. doi: 10.1038/283664a0.
4
Effect of interleukin 1 on human thymocytes and purified human T cells.白细胞介素1对人胸腺细胞和纯化的人T细胞的作用。
J Exp Med. 1981 Feb 1;153(2):470-5. doi: 10.1084/jem.153.2.470.
5
T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation.用于分析白细胞介素1介导的T细胞活化的T细胞淋巴瘤模型。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1133-7. doi: 10.1073/pnas.78.2.1133.
6
The functional relationship of the interleukins.白细胞介素的功能关系。
J Exp Med. 1980 Jun 1;151(6):1551-6. doi: 10.1084/jem.151.6.1551.
7
TCGF production for cloning and growth of functional human T lymphocytes.用于功能性人类T淋巴细胞克隆和生长的TCGF生产。
Scand J Immunol. 1980;12(2):149-54. doi: 10.1111/j.1365-3083.1980.tb00051.x.
8
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
9
Control of lymphokine secretion by prostaglandins.前列腺素对淋巴因子分泌的调控
Nature. 1976 Jul 29;262(5567):401-2. doi: 10.1038/262401a0.
10
Prostaglandins as regulators in cellular immunity.
Prostaglandins Med. 1978 Sep;1(3):183-99. doi: 10.1016/0161-4630(78)90105-2.

前列腺素E抑制人白细胞介素2的产生。

Prostaglandin E inhibits the production of human interleukin 2.

作者信息

Rappaport R S, Dodge G R

出版信息

J Exp Med. 1982 Mar 1;155(3):943-8. doi: 10.1084/jem.155.3.943.

DOI:10.1084/jem.155.3.943
PMID:6977613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186623/
Abstract

Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production. The resultant nonadherent cell population lost sensitivity to the enhancement effect of PG synthetase inhibitors, suggesting that a PGE-producing adherent cell plays a major role in the regulation of IL-2.

摘要

E型前列腺素能特异性抑制正常人淋巴细胞产生白细胞介素2（IL-2），而吲哚美辛和芬替酸等PG合成酶抑制剂可使IL-2产生量高于正常水平。从单核细胞群体中去除黏附细胞也会导致IL-2产生增加。由此产生的非黏附细胞群体对PG合成酶抑制剂的增强作用失去敏感性，这表明产生PGE的黏附细胞在IL-2的调节中起主要作用。