前列腺素E抑制人白细胞介素2的产生。
Prostaglandin E inhibits the production of human interleukin 2.
作者信息
Rappaport R S, Dodge G R
出版信息
J Exp Med. 1982 Mar 1;155(3):943-8. doi: 10.1084/jem.155.3.943.
Abstract
Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production. The resultant nonadherent cell population lost sensitivity to the enhancement effect of PG synthetase inhibitors, suggesting that a PGE-producing adherent cell plays a major role in the regulation of IL-2.
摘要
E型前列腺素能特异性抑制正常人淋巴细胞产生白细胞介素2（IL-2），而吲哚美辛和芬替酸等PG合成酶抑制剂可使IL-2产生量高于正常水平。从单核细胞群体中去除黏附细胞也会导致IL-2产生增加。由此产生的非黏附细胞群体对PG合成酶抑制剂的增强作用失去敏感性，这表明产生PGE的黏附细胞在IL-2的调节中起主要作用。
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