Gramer E, Jeschke R, Krieglstein G K
Klin Padiatr. 1982 Jan;194(1):52-5. doi: 10.1055/s-2008-1033771.
Computerized perimetry of the central visual field (Competer) was utilized in 12 eyes of children treated with Ethambutol because of tuberculosis to verify potential visual hazards of the drug. Visual acuity, visual field and the mean retinal threshold of the central field revealed no significant changes with increasing cumulative Ethambutol dose up to 166.5 g. The visual field was re-checked five times with a consecutive time lapse of 7 weeks. It can be concluded that the critical total dose of 150 g that is considered to be potential dangerous in adults does not affect the optic nerve of the infant either. Since this total dose can be exceeded in the continued treatment of the disease parents should be aware of the necessity of repeated visual field examinations or color vision testing. This concern is especially valid in infants suffering from renal tuberculosis because of higher plasma levels of the drug when excretion is prolonged.
对12名因结核病接受乙胺丁醇治疗的儿童的眼睛进行了中心视野计算机视野计检查（Competer），以验证该药物潜在的视觉危害。视力、视野和中心视野的平均视网膜阈值显示，在累积乙胺丁醇剂量增加至166.5克时，未发现显著变化。连续7周的时间间隔，对视野进行了5次重新检查。可以得出结论，在成人中被认为有潜在危险的150克临界总剂量对婴儿的视神经也没有影响。由于在疾病的持续治疗中可能会超过这个总剂量，家长应该意识到重复进行视野检查或色觉测试的必要性。这种担忧在患有肾结核的婴儿中尤为重要，因为排泄延长时药物的血浆水平较高。
