Kindred B, Bösing-Schneider R
Scand J Immunol. 1981 Nov;14(5):503-8.
The supernatant from concanavalin-A-treated cultures has been used in vivo in nude mice to investigate the nature of the antibody response that can be induced after injection of this non-specific T-cell replacing factor (NSF). Although NSF alone does not induce a response, it permits a greatly augmented response to sheep erythrocytes. This response is, however, restricted to IgM and is not accompanied by development of memory. No secondary response could be obtained with antigen alone or with NSF and antigen, and there was usually no response even if normal congenic thymus cells were injected with antigen into animals that had responded to NSF and antigen.
伴刀豆球蛋白A处理的培养物的上清液已在裸鼠体内用于研究注射这种非特异性T细胞替代因子（NSF）后可诱导的抗体反应的性质。虽然单独的NSF不会诱导反应，但它能使对绵羊红细胞的反应大大增强。然而，这种反应仅限于IgM，且不伴有记忆的形成。单独使用抗原或NSF与抗原联合使用均无法获得二次反应，并且即使将正常同基因胸腺细胞与抗原一起注射到对NSF和抗原产生反应的动物体内，通常也没有反应。
