Lydyard P M, Fanger M W
Scand J Immunol. 1981 Nov;14(5):509-14.
Lymphocyte populations expressing receptors for IgA (RFc alpha) in several human lymphoid tissues were numerically evaluated using a highly sensitive and specific indicator system. The percentages of RFc alpha-bearing lymphocytes were, in thymus, 9%; bone marrow, 14%; tonsil, 38%; cord blood, 34%; and adult blood, 55%. In adult and cord blood, RFc alpha were primarily associated with the T-lymphocyte populations as defined by their ability to bind sheep erythrocytes (SE). A large percentage of the peripheral T-lymphocyte population expressed both RFc alpha and receptors for IgM (RFcmu), whereas few T lymphocytes expressing receptors for IgG also displayed RFc alpha. Although a small number of peripheral non-T cells also expressed RFc alpha, they appeared to have fewer or less avid receptors than the RFc alpha-bearing T lymphocyte population. Both bone marrow and tonsil lymphocytes of both T and non-T populations expressed RFc alpha. Furthermore, the RFc alpha-bearing non-T population in both tonsil and bone marrow was quite large, 39 and 26%, respectively. These studies document the ubiquity of RFc alpha and its expression on the same peripheral lymphocyte population as RFcmu and indicate that RFc alpha is associated with several functionally different lymphocyte subpopulations including those involved in regulation (help) and antibody-dependent cell cytotoxicity.
使用高度敏感且特异的指示系统，对几个人类淋巴组织中表达IgA受体（RFcα）的淋巴细胞群体进行了数量评估。胸腺中携带RFcα的淋巴细胞百分比为9%；骨髓为14%；扁桃体为38%；脐血为34%；成人血液为55%。在成人血液和脐血中，RFcα主要与通过结合绵羊红细胞（SE）能力定义的T淋巴细胞群体相关。外周T淋巴细胞群体中很大比例同时表达RFcα和IgM受体（RFcmu），而表达IgG受体的T淋巴细胞中很少有同时显示RFcα的。尽管少数外周非T细胞也表达RFcα，但它们的受体数量似乎比携带RFcα的T淋巴细胞群体更少或亲和力更低。骨髓和扁桃体中的T和非T淋巴细胞群体均表达RFcα。此外，扁桃体和骨髓中携带RFcα的非T群体相当大，分别为39%和26%。这些研究证明了RFcα的普遍性及其与RFcmu在同一外周淋巴细胞群体上的表达，并表明RFcα与几个功能不同的淋巴细胞亚群相关，包括参与调节（辅助）和抗体依赖性细胞毒性的亚群。
