Dale J
Scand J Haematol Suppl. 1981;38:131-41.
Aorto-coronary saphenous vein bypass graft implantation has led to a considerable relief of angina in a great majority of patients. Their functional capacity has been increased, and life possibly prolonged. During the postoperative period approximately ten per cent of the grafts occlude because of thrombosis, and later 2-3 per cent occlude per year. The angina returns in some patients, which is related either to graft closure or to progression of arteriosclerotic disease in the coronary arteries. A randomized clinical study has therefore been started in 142 patients in order to prevent graft closure. Two to three days after operation, one group of 72 receive acetylsalicylic acid, one gm. daily, and anticoagulants, while the 70 patients in the control group receive no antithrombotic drugs, and are asked to avoid anti-inflammatory agents. After 18 to 24 months, they are admitted for follow-up, including re-catheterization with selective angiography of coronary arteries or grafts. The effect of therapy will be assessed from graft potency alone.
主动脉 - 冠状动脉大隐静脉旁路移植术已使绝大多数患者的心绞痛得到显著缓解。他们的功能能力得到了提高，寿命可能得以延长。在术后期间，约10%的移植物因血栓形成而闭塞，随后每年有2 - 3%的移植物闭塞。部分患者心绞痛复发，这与移植物闭塞或冠状动脉粥样硬化疾病进展有关。因此，针对142例患者开展了一项随机临床研究以预防移植物闭塞。术后2至3天，一组72例患者每日服用1克乙酰水杨酸及抗凝剂，而对照组的70例患者不服用抗血栓药物，并被要求避免使用抗炎药物。18至24个月后，他们入院进行随访，包括再次进行冠状动脉或移植物的选择性血管造影导管插入术。治疗效果将仅根据移植物效能进行评估。
