真性红细胞增多症中的脑血流量

Cerebral blood-flow in polycythaemia.

作者信息

Thomas D J, du Boulay G H, Marshall J, Pearson T C, Ross Russell R W, Symon L, Wetherley-Mein G, Zilkha E

出版信息

Lancet. 1977 Jul 23;2(8030):161-3. doi: 10.1016/s0140-6736(77)90179-9.

Abstract

Cerebral blood-flow (C.B.F.) has been measured in 16 patients with polycythaemia of differing severity. The mean C.B.F. was 37-9 ml/100 g/min, which is significantly below the normal level of 69-1 (S.D. 9-3) ml/100 g/min (P less than 0-001). C.B.F. measurement was repeated after venesection in 15 of the patients. Lowering the haematocrit from a mean of 0-536 to a mean of 0-455 was associated with a 73% increase in mean C.B.F. (P less than 0-001) and a 30% reduction in whole-blood viscosity. Low C.B.F. was found at haematocrit levels between 0-46 and 0-52. Haematocrit levels that are currently acceptable in the management of polycythaemia may therefore be too high.

摘要

对16例不同严重程度的红细胞增多症患者进行了脑血流量（C.B.F.）测量。平均脑血流量为37 - 9毫升/100克/分钟，显著低于正常水平69 - 1（标准差9 - 3）毫升/100克/分钟（P小于0 - 001）。15例患者在放血后重复进行了脑血流量测量。血细胞比容从平均0 - 536降至平均0 - 455，平均脑血流量增加了73%（P小于0 - 001），全血粘度降低了30%。在血细胞比容水平介于0 - 46和0 - 52之间时发现脑血流量较低。因此，目前红细胞增多症管理中可接受的血细胞比容水平可能过高。