Koch G, Benner R
Immunology. 1982 Apr;45(4):697-704.
During the secondary response of mice to T-dependent antigens, antibody-producing plaque-forming cells (PFC) appear not only in peripheral lymphoid organs, but also in the bone marrow. This bone marrow antibody formation is feeble after primary immunization. The capacity of bone marrow antibody formation is dependent on the presence of antigen-specific memory cells at the moment of secondary immunization. We investigated whether hapten-primed B memory, carrier-primed T memory or both B-memory and T-memory cells are required for the adoptive PFC response in the bone marrow to T-dependent hapten-carrier conjugates. Adoptive antibody formation in the bone marrow was found after transfer of hapten-primed spleen cells, but not after transfer of carrier-primed spleen cells or virgin spleen cells. Thus, B-memory cells are obligatory for adoptive antibody formation in the bone marrow, in contrast to T-memory cells. However, T-memory cells did facilitate the bone marrow PFC response mediated by the infused B-memory cells.
在小鼠对胸腺依赖性抗原的二次应答过程中，产生抗体的噬斑形成细胞（PFC）不仅出现在外周淋巴器官中，也出现在骨髓中。初次免疫后，这种骨髓抗体形成较为微弱。骨髓抗体形成的能力取决于二次免疫时抗原特异性记忆细胞的存在。我们研究了对半抗原致敏的B记忆细胞、对载体致敏的T记忆细胞，或者B记忆细胞和T记忆细胞两者，是否是骨髓中对胸腺依赖性半抗原-载体偶联物产生过继性PFC应答所必需的。在转移对半抗原致敏的脾细胞后，发现骨髓中有过继性抗体形成，但在转移对载体致敏的脾细胞或未致敏的脾细胞后则未发现。因此，与T记忆细胞不同，B记忆细胞是骨髓中过继性抗体形成所必需的。然而，T记忆细胞确实促进了由注入的B记忆细胞介导的骨髓PFC应答。
