Shinozaki T, Meguro H, Koike Y, Hashira S, Fujii R
Jpn J Antibiot. 1982 Jan;35(1):251-60.
MOM was administered at a daily dose of 20 to 40 mg/kg q.i.d. orally to 65 pediatric patients. These consisted of 37 cases of acute feverish respiratory tract infection, 13 cases of Mycoplasma infection, 1 case of scarlet fever and 14 cases of whooping cough. Forty pathogenic bacteria were isolated from the 37 patients with acute feverish respiratory tract infection and 1 pathogenic bacteria was isolated from the patient with scarlet fever. Thirty-five of these clinical isolates disappeared as a result of MOM administration. For these 65 cases, the clinical efficacy was good in 51 cases (78.5%), fair in 5 cases (all whooping cough) and poor in 9 cases. Twelve strains of St. pyogenes were isolated from 12 cases and 3 of these isolates persisted (25%). Ten strains of S. aureus were isolated from 10 cases and 1 of these isolates persisted. Superinfection was observed in 3 cases, 2 of which were the same species. Although the clinical effect in the 40 mg/kg/day treatment group was superior to the effects in the 20 mg/kg/day and 30 mg/kg/day treatment groups, the difference was not statistically significant.
对65例儿科患者口服给予胃蛋白酶，每日剂量为20至40mg/kg，每日4次。其中包括37例急性发热性呼吸道感染、13例支原体感染、1例猩红热和14例百日咳。从37例急性发热性呼吸道感染患者中分离出40株病原菌，从猩红热患者中分离出1株病原菌。这些临床分离株中有35株因给予胃蛋白酶而消失。对于这65例病例，临床疗效良好的有51例（78.5%），中等的有5例（均为百日咳），差的有9例。从12例中分离出12株化脓性链球菌，其中3株分离株持续存在（25%）。从10例中分离出10株金黄色葡萄球菌，其中1株分离株持续存在。观察到3例二重感染，其中2例为同一菌种。虽然40mg/kg/天治疗组的临床效果优于20mg/kg/天和30mg/kg/天治疗组，但差异无统计学意义。
