2,4-二氧代-1,2,3,4-四氢喹唑啉某些衍生物的合成与生物活性。第2部分。
Synthesis and biological activity of certain derivatives of 2,4-dioxo-1,2,3,4-tetrahydroquinazoline. Part 2.
作者信息
Khalifa M, Osman A N, Ibrahim M G, el Rahman A, Ossman E, Ismail M A
出版信息
Pharmazie. 1982 Feb;37(2):115-7.
PMID:6978491
Abstract
The synthesis of 6-bromo-1-ethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline, its benzoyl and its benzyl derivatives is described. The unreported 5-bromo-N-phenyl-anthranilic acid was synthesized from anthranilic acid adopting a procedure, which involved a novel synthesis of 2,5-dibromobenzoic acid. Direct bromination of N-phenylanthranilic acid and N-p-tolyl-anthranilic acid afforded the tribromo-and dibromoderivatives respectively.
摘要
描述了6-溴-1-乙基-2,4-二氧代-1,2,3,4-四氢喹唑啉及其苯甲酰基和苄基衍生物的合成。采用一种涉及2,5-二溴苯甲酸新合成方法，从邻氨基苯甲酸合成了未报道的5-溴-N-苯基邻氨基苯甲酸。N-苯基邻氨基苯甲酸和N-对甲苯基邻氨基苯甲酸的直接溴化分别得到三溴和二溴衍生物。
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