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[结核病的细胞介导免疫和体液免疫]

[Cellular mediated and humoral immunity of tuberculosis].

作者信息

Awerbach M M, Moros A M, Litvinov W I

出版信息

Z Erkr Atmungsorgane. 1982;158(1-2):243-50.

PMID:6978575
Abstract

Review on cellular mediated and humoral immunity in tuberculosis, the research of which Robert Koch has fundamentally initiated. Problems of immunity are playing a role in the course of tuberculous infection and disease, in BCG-vaccination and in therapy. T-lymphocytes and activated macrophage system contribute to regulate resistance to tuberculous infection. the role of antituberculous antibodies in the course of tuberculous is still not fully clear. Genetic control mechanisms of immune response seem to exit also in tuberculosis, observed in animal experiments (mice). There can be selected 2 lines of animals with with quite different tuberculous resistance, highly sensible and more resistant strains to tuberculous infection, reacting also differently in their immune response. Immunological methods have a significance already obvious for estimation of prognosis.

摘要

关于结核病中细胞介导免疫和体液免疫的综述,其研究由罗伯特·科赫从根本上开启。免疫问题在结核感染和疾病过程、卡介苗接种及治疗中都发挥着作用。T淋巴细胞和活化的巨噬细胞系统有助于调节对结核感染的抵抗力。抗结核抗体在结核病过程中的作用仍不完全清楚。在动物实验(小鼠)中观察到,免疫反应的遗传控制机制似乎在结核病中也存在。可以选择出对结核具有截然不同抵抗力的两系动物,即对结核感染高度敏感和抵抗力更强的品系,它们在免疫反应中也表现出不同。免疫方法对预后评估的意义已经很明显。

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