Néliat G, Moreau M, Ducouret P, Gargouïl Y M
Arch Int Pharmacodyn Ther. 1982 Feb;255(2):220-36.
The electrophysiological effects of butoprozine, a relatively new antiarrhythmic agent, were investigated in sheep cardiac Purkinje fibres using a microelectrode technique and in frog atrial and ferret ventricular fibres using a double sucrose gap technique. Comparison was made with amiodarone and verapamil. Butoprozine increased the action potential duration like amiodarone, depressed the plateau phase like verapamil and decreased the amplitude and the maximum rate of depolarization. Pacemaker activity in Purkinje fibres and repetitive activity in frog atrium were inhibited by the three drugs. The inhibition of automaticity was related to a reduction of the slope of diastolic depolarization in both tissues by butoprozine and amiodarone. The results confirm that butoprozine possesses a potent antiarrhythmic activity. It acts by mechanisms common to amiodarone and verapamil.
使用微电极技术在绵羊心脏浦肯野纤维中，以及使用双蔗糖间隙技术在青蛙心房和雪貂心室纤维中，研究了一种相对较新的抗心律失常药物布托丙嗪的电生理效应。并与胺碘酮和维拉帕米进行了比较。布托丙嗪像胺碘酮一样增加动作电位持续时间，像维拉帕米一样抑制平台期，并降低振幅和最大去极化速率。三种药物均抑制浦肯野纤维的起搏活动和青蛙心房的重复活动。布托丙嗪和胺碘酮对这两种组织舒张期去极化斜率的降低与自动节律性的抑制有关。结果证实布托丙嗪具有强效抗心律失常活性。其作用机制与胺碘酮和维拉帕米相同。
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