Celestino Daniela, Medei Emiliano, Moro Sandra, Elizari Marcelo V, Sicouri Serge
Laboratorio de Electrofisiología Celular División Cardiología, Hospital Ramos Mejía, Buenos Aires, Argentina.
J Cardiovasc Pharmacol Ther. 2007 Sep;12(3):248-57. doi: 10.1177/1074248407303225.
Amiodarone is a potent antiarrhythmic drug commonly used in the treatment of supraventricular and ventricular arrhythmias. Dronedarone is a recently developed iodine-free compound (Sanofi Recherche), structurally related to amiodarone. Amiodarone and dronedarone have shown similar long-term effects on sinoatrial node automaticity in vivo and in vitro in the rabbit heart. In the present study, we used a microelectrode technique to compare the acute in vitro electrophysiologic effects of amiodarone (100 microM) and dronedarone (100 microM) on the rabbit sinus node. Like amiodarone, dronedarone induces a marked reduction in sinus node automaticity, evidenced by decreases in spontaneous beating rate, action potential amplitude, and slope of phase 4 depolarization. Isoproterenol dose-dependently increases sinus node automaticity in the presence of either amiodarone or dronedarone. The data suggest that dronedarone may be a useful antiarrhythmic alternative to amiodarone in the treatment of supraventricular arrhythmias.
胺碘酮是一种强效抗心律失常药物，常用于治疗室上性和室性心律失常。决奈达隆是一种最近研发的无碘化合物（赛诺菲研究公司），在结构上与胺碘酮相关。胺碘酮和决奈达隆在体内外对兔心脏窦房结自律性均显示出相似的长期影响。在本研究中，我们使用微电极技术比较了胺碘酮（100微摩尔）和决奈达隆（100微摩尔）对兔窦房结的急性体外电生理效应。与胺碘酮一样，决奈达隆可显著降低窦房结自律性，表现为自发搏动频率、动作电位幅度和4期去极化斜率降低。在存在胺碘酮或决奈达隆的情况下，异丙肾上腺素可剂量依赖性地增加窦房结自律性。数据表明，在治疗室上性心律失常方面，决奈达隆可能是胺碘酮的一种有用的抗心律失常替代药物。
