哺乳动物皮肤中细胞色素P-450依赖的O-脱烷基酶活性。
Cytochrome P-450-dependent O-dealkylase activity in mammalian skin.
作者信息
Damen F J, Mier P D
出版信息
Br J Pharmacol. 1982 Jan;75(1):123-7. doi: 10.1111/j.1476-5381.1982.tb08764.x.
Abstract
1 A modified technique for the measurement of O-dealkylase (ODA) activity in crude homogenates is reported, and its application to skin is described. 2 Large differences in ODA levels were found between different species, no activity being observed in the skin of primates. 3 Induction of cutaneous ODA in mice was achieved by the subcutaneous injection of phenobarbitone, hexachlorobenzene or 20-methylcholanthrene. 4 Attempts to induce ODA in vitro were unsuccessful.
摘要
- 本文报道了一种用于测量粗匀浆中O-脱烷基酶（ODA）活性的改良技术，并描述了其在皮肤中的应用。2. 发现不同物种之间的ODA水平存在很大差异，在灵长类动物的皮肤中未观察到活性。3. 通过皮下注射苯巴比妥、六氯苯或20-甲基胆蒽可诱导小鼠皮肤中的ODA。4. 体外诱导ODA的尝试未成功。
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