Hadlock F P, Harrist R B, Deter R L, Park S K
AJR Am J Roentgenol. 1982 May;138(5):875-8. doi: 10.2214/ajr.138.5.875.
The relation between fetal femur length and menstrual age was determined by cross-sectional analysis of 338 normal fetuses (12--40 weeks) using real-time sonography. Mathematical modeling of the data demonstrated that the femur growth curve is nonlinear, similar to the biparietal diameter growth curve. Predicted femur length values at various points in gestation were comparable to the results of other investigators. Predicted menstrual age values in weeks for specific femur length measurements in millimeters were calculated and are reported in tabular form. The variability (+/- 2 SD) associated with predicting menstrual age from femur length is +/- 9.5 days between 12--23 weeks, but between 23--40 weeks the variability is +/- 22 days. Fetal femur length can be used as an adjunct in estimating menstrual age, and as a screening device for diseases that affect fetal limb growth (e.g., dwarfism, osteogenesis imperfecta).
通过实时超声对338例正常胎儿（孕12 - 40周）进行横断面分析，确定了胎儿股骨长度与月经龄之间的关系。数据的数学建模表明，股骨生长曲线是非线性的，类似于双顶径生长曲线。妊娠各阶段的预测股骨长度值与其他研究者的结果相当。计算了以毫米为单位的特定股骨长度测量值对应的以周为单位的预测月经龄值，并以表格形式报告。根据股骨长度预测月经龄的变异度（±2标准差）在孕12 - 23周时为±9.5天，但在孕23 - 40周时为±22天。胎儿股骨长度可作为估计月经龄的辅助手段，以及用于筛查影响胎儿肢体生长的疾病（如侏儒症、成骨不全症）。
