小儿患者中克拉维酸钾与阿莫西林联合使用的药代动力学
Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients.
作者信息
Nelson J D, Kusmiesz H, Shelton S
出版信息
Antimicrob Agents Chemother. 1982 Apr;21(4):681-2. doi: 10.1128/AAC.21.4.681.
Abstract
Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With a greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 micrograms clavulanic acid per ml and 4.9 micrograms amoxicillin per ml.
摘要
在34名婴幼儿和儿童中对两种剂量的阿莫西林克拉维酸钾液体悬浮制剂进行了测试。较小剂量导致血浆浓度未达最佳水平。使用较大剂量（每千克体重3.3毫克克拉维酸和每千克体重13.3毫克阿莫西林）时，平均血浆峰浓度为每毫升1.6微克克拉维酸和每毫升4.9微克阿莫西林。
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