Lehnhardt E, Schmidt W, Franke K D
Arch Otorhinolaryngol. 1982;234(1):73-95. doi: 10.1007/BF00453540.
The central neural hearing disorders - in contrast to central cortical lesions - can be concretely defined audiometrically, and they can be localized realiably within the 2nd-4th neurons. For this purpose a definite test program is needed; especially indicative are the behavior of the acoustico-facial stapedius reflex and the results in dichotic discrimination and ERA. SISI and difference limen mostly point to a neural dysfunction, but - in distinct patterns of impairment - they may correspond to the picture of a peripheral hearing disorder as well. A fatigue of hearing apparently only appears if the myelin is damaged, at - perhaps additional - axonal lesions it shows up less clearly or not at all. The deficiency pattern of the stapedius reflex reflects up less clearly or not at all. The deficiency pattern of the stapedius reflex reflects the course of the reflex arc within the brain stem; accordingly, more central lesions of the auditory pathway do not affect the reflex. ERA mostly makes perceivable a lesion of synchronization, which only becomes noticeable at fast repetition rates with ultra short stimuli (1/4 ms), i.e., solely in the responses of the brain stem. The cortical responses, on the contrary, are not impaired more than the subjective threshold renders to be expected, they even show the same values of the pure tone audiogram. The dichotic discrimination is nearly always disturbed unilaterally, at processes of the brain stem homolaterally, at cortical foci predominantly leftside, perhaps because the left hemisphere dominates in speech discrimination. The otologist should know how to make use of the possibility of neuro-otologic diagnostics.
与中枢皮质病变不同,中枢神经性听力障碍可以通过听力测定具体界定,并且可以在第二至第四神经元内可靠定位。为此需要一个明确的测试程序;听面镫骨肌反射的表现以及双耳辨别和听性脑干反应的结果尤其具有指示性。短增量敏感指数(SISI)和差别阈限大多指向神经功能障碍,但在不同的损伤模式下,它们也可能与外周听力障碍的情况相符。听力疲劳显然只有在髓鞘受损时才会出现,在可能存在的额外轴突病变时,其表现不那么明显或根本不出现。镫骨肌反射的缺陷模式反映脑干内反射弧的情况;因此,听觉通路更中枢性的病变不会影响该反射。听性脑干反应大多能察觉到同步性病变,这种病变只有在超短刺激(1/4毫秒)的快速重复率下才会明显,即仅在脑干的反应中出现。相反,皮质反应受损程度不超过主观阈值预期的程度,甚至与纯音听力图的值相同。双耳辨别几乎总是单侧受扰,在脑干病变时为同侧,在皮质病灶时主要为左侧,这可能是因为左半球在言语辨别中占主导地位。耳科医生应该知道如何利用神经耳科学诊断的可能性。