Rahimtoola S H
Circulation. 1982 Jun;65(7 Pt 2):106-14. doi: 10.1161/01.cir.65.7.106.
Many studies have demonstrated that coronary artery bypass surgery combined with medical therapy produces a greater degree of improvement in the symptomatic state and in the functional class of the patients with severe coronary artery disease than does medical therapy alone. This can be objectively documented by an improvement in the exercise capacity and by an increase in heart rate and blood pressure attained at the higher level of exercise. The improvement is the result of relief of exercise-induced (and resting) myocardial ischemia documented by increases in heart rate and blood pressure, greater lactate extraction across the myocardium, improvement in left ventricular dysfunction, abolition of exertional hypotension, and by reversal of exercise-induced and of resting thallium-201 defects. Results of coronary bypass surgery performed during 1974-1979 are better than those during 1969-1973.
许多研究表明,对于患有严重冠状动脉疾病的患者,冠状动脉搭桥手术联合药物治疗在症状状态和功能分级方面比单纯药物治疗能产生更大程度的改善。这可以通过运动能力的提高以及在更高运动水平时心率和血压的增加来客观证明。这种改善是运动诱发(及静息)心肌缺血得到缓解的结果,其表现为心率和血压增加、心肌乳酸摄取增加、左心室功能障碍改善、运动性低血压消失以及运动诱发和静息铊-201缺损的逆转。1974 - 1979年进行的冠状动脉搭桥手术结果优于1969 - 1973年期间的结果。