苯恶洛芬对大鼠Ⅱ型胶原诱导性关节炎的炎症、体液及细胞成分的影响。
Effects of benoxaprofen on the inflammatory, humoral and cellular components of type II collagen-induced arthritis in rats.
作者信息
Phadke K, Nanda S
出版信息
Eur J Rheumatol Inflamm. 1982;5(2):170-4.
The effects of benoxaprofen and some other anti-inflammatory drugs on the inflammatory, cellular, and humoral components of type II collagen-induced arthritis in rats were studied. At the given dosage (mg/kg/day), benoxaprofen (10), aspirin (25), and indomethacin (3) inhibited the hindpaw swelling and development of anti-type II collagen antibodies in collagen-treated rats. Benoxaprofen also inhibited the delayed-type hypersensitivity response to collagen. Phenylbutazone (30) failed to show significant effect on these parameters. The treatment of rats with benoxaprofen throughout the test period or during days 14 to 28 was more effective than the treatment in the initial phases only.
研究了贝诺洛芬及其他一些抗炎药对大鼠Ⅱ型胶原诱导性关节炎的炎症、细胞和体液成分的影响。在给定剂量（mg/kg/天）下，贝诺洛芬（10）、阿司匹林（25）和吲哚美辛（3）可抑制胶原处理大鼠的后爪肿胀及抗Ⅱ型胶原抗体的产生。贝诺洛芬还可抑制对胶原的迟发型超敏反应。保泰松（30）对这些参数未显示出显著影响。在整个试验期或第14至28天用贝诺洛芬治疗大鼠比仅在初始阶段治疗更有效。
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