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9
The role of neutrophils in type II collagen-induced arthritis in rats.中性粒细胞在大鼠Ⅱ型胶原诱导性关节炎中的作用。
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本文引用的文献

1
Autoimmunity to collagen in adjuvant arthritis of rats.大鼠佐剂性关节炎中对胶原蛋白的自身免疫反应。
J Clin Invest. 1980 Nov;66(5):1109-17. doi: 10.1172/JCI109940.
2
Cell-mediated immunity to collagen and collagen alpha chains in rheumatoid arthritis and other rheumatic diseases.类风湿关节炎及其他风湿性疾病中针对胶原蛋白和胶原蛋白α链的细胞介导免疫。
Am J Med. 1980 Jul;69(1):13-8. doi: 10.1016/0002-9343(80)90494-5.
3
Collagen-induced polyarthritis in rats: a study of native type II collagen for adjuvant activity.大鼠胶原诱导性多关节炎：天然II型胶原佐剂活性的研究
J Immunol. 1980 Jun;124(6):2912-8.
4
Gold does not alter the arthritic, humoral, or cellular responses in rats with type II collagen-induced arthritis.金不会改变II型胶原诱导性关节炎大鼠的关节炎、体液或细胞反应。
Arthritis Rheum. 1980 Aug;23(8):932-6. doi: 10.1002/art.1780230809.
5
Genetic control of the murine T lymphocyte proliferative response to collagen: analysis of the molecular and cellular contributions to immunogenicity.小鼠T淋巴细胞对胶原蛋白增殖反应的遗传控制：对免疫原性的分子和细胞贡献分析
J Immunol. 1980 Jun;124(6):2854-9.
6
Immunisation against heterologous type II collagen induces arthritis in mice.针对异源II型胶原蛋白进行免疫接种会在小鼠中诱发关节炎。
Nature. 1980 Feb 14;283(5748):666-8. doi: 10.1038/283666a0.
7
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
8
Glutaraldehyde, cyanuric chloride and tetrazotized O-dianisidine as coupling reagents in the passive hemagglutination test.戊二醛、三聚氯氰和四氮唑化邻联茴香胺作为被动血凝试验中的偶联试剂。
Immunochemistry. 1969 Jan;6(1):67-76. doi: 10.1016/0019-2791(69)90179-7.
9
Rheumatoid vasculitis. Report of a second case treated with penicillamine.类风湿性血管炎。第二例用青霉胺治疗的病例报告。
Arthritis Rheum. 1968 Aug;11(4):585-92. doi: 10.1002/art.1780110408.
10
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.

各种抗炎药物对大鼠II型胶原诱导性关节炎的影响。

Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats.

作者信息

Phadke K, Carroll J, Nanda S

出版信息

Clin Exp Immunol. 1982 Mar;47(3):579-86.

PMID:6979443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536430/
Abstract

The effects of some commonly used anti-inflammatory and anti-arthritic drugs on the inflammatory and immunological manifestations of type II collagen-induced arthritis in rats were studied. Among the anti-inflammatory drugs tested at a given dosage (mg/kg/day), benoxaprofen (10), aspirin (25) and indomethacin (3) inhibited the hind paw swelling and anti-type II collagen antibody formation in type II collagen-treated rats. Benoxaprofen also inhibited the delayed type hypersensitivity (DTH) response to type II collagen. Phenylbutazone (30) and fenoprofen (40) partially suppressed the paw swelling, but had no significant effect on humoral and cellular responses. Among the other anti-arthritic drugs, levamisol (25), chloroquine (25) and D-penicillamine significantly suppressed the paw swelling, anti-type II collagen antibody titres and DTH response. Gold chlorophosphene (10) and colchicine (3) had no effect on any of these three parameters. Paramethasone (0.1), cyclophosphamide (1) and azathioprine (10) were very effective when dosed daily, or once (at a different dose) 72 hr prior to immunization with type II collagen.

摘要

研究了一些常用抗炎和抗关节炎药物对大鼠Ⅱ型胶原诱导性关节炎的炎症和免疫表现的影响。在所测试的抗炎药物中，按给定剂量（mg/kg/天）给药时，贝诺洛芬（10）、阿司匹林（25）和吲哚美辛（3）可抑制Ⅱ型胶原处理大鼠的后爪肿胀和抗Ⅱ型胶原抗体形成。贝诺洛芬还可抑制对Ⅱ型胶原的迟发型超敏反应（DTH）。保泰松（30）和非诺洛芬（40）部分抑制爪肿胀，但对体液和细胞反应无显著影响。在其他抗关节炎药物中，左旋咪唑（25）、氯喹（25）和D-青霉胺可显著抑制爪肿胀、抗Ⅱ型胶原抗体滴度和DTH反应。三氯金磷（10）和秋水仙碱（3）对这三个参数均无影响。每日给药，或在Ⅱ型胶原免疫前72小时（以不同剂量）给药一次时，对甲米松（0.1）、环磷酰胺（1）和硫唑嘌呤（10）非常有效。