各种抗炎药物对大鼠II型胶原诱导性关节炎的影响。
Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats.
作者信息
Phadke K, Carroll J, Nanda S
出版信息
Clin Exp Immunol. 1982 Mar;47(3):579-86.
The effects of some commonly used anti-inflammatory and anti-arthritic drugs on the inflammatory and immunological manifestations of type II collagen-induced arthritis in rats were studied. Among the anti-inflammatory drugs tested at a given dosage (mg/kg/day), benoxaprofen (10), aspirin (25) and indomethacin (3) inhibited the hind paw swelling and anti-type II collagen antibody formation in type II collagen-treated rats. Benoxaprofen also inhibited the delayed type hypersensitivity (DTH) response to type II collagen. Phenylbutazone (30) and fenoprofen (40) partially suppressed the paw swelling, but had no significant effect on humoral and cellular responses. Among the other anti-arthritic drugs, levamisol (25), chloroquine (25) and D-penicillamine significantly suppressed the paw swelling, anti-type II collagen antibody titres and DTH response. Gold chlorophosphene (10) and colchicine (3) had no effect on any of these three parameters. Paramethasone (0.1), cyclophosphamide (1) and azathioprine (10) were very effective when dosed daily, or once (at a different dose) 72 hr prior to immunization with type II collagen.
研究了一些常用抗炎和抗关节炎药物对大鼠Ⅱ型胶原诱导性关节炎的炎症和免疫表现的影响。在所测试的抗炎药物中，按给定剂量（mg/kg/天）给药时，贝诺洛芬（10）、阿司匹林（25）和吲哚美辛（3）可抑制Ⅱ型胶原处理大鼠的后爪肿胀和抗Ⅱ型胶原抗体形成。贝诺洛芬还可抑制对Ⅱ型胶原的迟发型超敏反应（DTH）。保泰松（30）和非诺洛芬（40）部分抑制爪肿胀，但对体液和细胞反应无显著影响。在其他抗关节炎药物中，左旋咪唑（25）、氯喹（25）和D-青霉胺可显著抑制爪肿胀、抗Ⅱ型胶原抗体滴度和DTH反应。三氯金磷（10）和秋水仙碱（3）对这三个参数均无影响。每日给药，或在Ⅱ型胶原免疫前72小时（以不同剂量）给药一次时，对甲米松（0.1）、环磷酰胺（1）和硫唑嘌呤（10）非常有效。
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