Weinberger O, Germain R N, Springer T, Burakoff S J
J Immunol. 1982 Aug;129(2):694-7.
Under conditions in which antigen dose is suboptimal, the recognition of Ia determinants is a necessary component of the generation of allospecific CTL responses. With monoclonal anti-Ia antibodies used as blocking reagents, it is demonstrated that the recognition of alloantigens may proceed via two pathways. Alloantigens can be recognized in the context of syngeneic Ia determinants in a similar fashion to conventional antigens. If, however, the Ia+ cells are removed from the responder population, the generation of such responses involves the recognition of allogeneic Ia determinants directly. A non-T, non-B, adherent accessory cell was identified as the critical syngeneic Ia+ cell required for CTL responses in these cultures.
在抗原剂量次优的条件下，Ia 决定簇的识别是同种特异性细胞毒性 T 淋巴细胞（CTL）反应产生的必要组成部分。使用单克隆抗 Ia 抗体作为阻断试剂，结果表明同种抗原的识别可能通过两条途径进行。同种抗原可以在同基因 Ia 决定簇的背景下，以与传统抗原类似的方式被识别。然而，如果从反应细胞群体中去除 Ia⁺细胞，此类反应的产生则涉及直接识别异基因 Ia 决定簇。一种非 T、非 B 黏附性辅助细胞被确定为这些培养物中 CTL 反应所需的关键同基因 Ia⁺细胞。
