Selwyn A P, Allan R M, L'Abbate A, Horlock P, Camici P, Clark J, O'Brien H A, Grant P M
Am J Cardiol. 1982 Jul;50(1):112-21. doi: 10.1016/0002-9149(82)90016-9.
Experiments were undertaken using rubidium-82 and position tomography to examine the relation between myocardial perfusion and cation uptake during acute ischemia. Rubidium-82 was repeatedly eluted from a strontium-82-rubidium-82 generator. In six dogs emission tomograms were used to measure the delivered arterial and myocardial concentrations at rest and after coronary stenosis, stress and ischemia. There was a poor overall relation between regional myocardial uptake and flow measured by microspheres and a large individual variability. Extraction of rubidium-82 was inversely related to flow. Significant regional reduction of cation uptake was detected in the tomograms when regional flow decreased by more than 35 percent. This reduction was significantly greater when ischemia was present. A small but significantly greater when ischemia was present. A small but significant decrease (33.0 +/- 9.1 percent, mean +/- standard deviation) in the myocardial uptake of rubidium-82 was detected only when flow was increased by more than 120 percent in relation to a control area after administration of dypiridamole. The technique using rubidum-82 and tomography was applied in five volunteers and five patients with angina pectoris and coronary artery disease. Myocardial tomograms recorded at rest and after exercise in the volunteers showed homogeneous uptake of cation in reproducible and repeatable scans. In contrast, the patients with coronary artery disease showed an absolute mean decrease of 36 +/- 14 percent in regional myocardial uptake of rubidium-82 after exercise. These abnormalities persisted in serial tomograms for more than 20 minutes after the symptoms and electrocardiographic signs of ischemia.
采用铷 - 82和正电子断层扫描技术进行实验，以研究急性缺血期间心肌灌注与阳离子摄取之间的关系。铷 - 82从锶 - 82 - 铷 - 82发生器中反复洗脱。对6只狗进行了发射断层扫描，以测量静息状态、冠状动脉狭窄后、应激和缺血状态下的动脉输送浓度和心肌浓度。通过微球测量的局部心肌摄取与血流之间的总体相关性较差，且个体差异较大。铷 - 82的摄取与血流呈负相关。当局部血流减少超过35%时，在断层扫描中检测到阳离子摄取有明显的局部降低。当存在缺血时，这种降低更为显著。当存在缺血时，还有一个小但显著的降低。仅在给予双嘧达莫后，相对于对照区域血流增加超过120%时，才检测到铷 - 82心肌摄取有小但显著的降低（33.0±9.1%，平均值±标准差）。使用铷 - 82和断层扫描技术对5名志愿者和5名患有心绞痛和冠状动脉疾病的患者进行了研究。志愿者静息和运动后的心肌断层扫描显示，在可重复的扫描中阳离子摄取均匀。相比之下，冠状动脉疾病患者运动后铷 - 82局部心肌摄取的绝对平均降低了36±14%。这些异常在缺血症状和心电图体征出现后的系列断层扫描中持续超过20分钟。
