Agarwal S, Shukla H S, Verma M, Gupta S C, Mukherjee K
Ann Chir Gynaecol. 1982;71(2):117-21.
Cell-mediated immune responses were examined during the menstrual cycle of 10 healthy females and in 90 pregnant females, 10 for each month of gestation, and in 10 females 2--4 weeks after normal delivery. Lymphocytes and their subpopulations and PPD hypersensitivity skin tests were investigated. The lymphocyte subpopulation T-cells showed statistically significant depression at the time of ovulation (P less than 0.01) and during the entire period of gestation (P less than 0.001) with recovery in the post-partum period. There was borderline PPD skin response during pregnancy which became positive after parturition. These changes were demonstrated to be specific to conception but the exact mechanism of the T-cell depression is not known. There was a corresponding rise in the B-cell count.
对10名健康女性的月经周期、90名怀孕女性（孕期每个月10名）以及10名正常分娩后2 - 4周的女性进行了细胞介导免疫反应检测。研究了淋巴细胞及其亚群和PPD超敏皮肤试验。淋巴细胞亚群T细胞在排卵时（P<0.01）和整个孕期（P<0.001）出现统计学上的显著降低，产后恢复。孕期PPD皮肤反应处于临界状态，产后转为阳性。这些变化被证明是受孕所特有的，但T细胞降低的确切机制尚不清楚。B细胞计数相应升高。
