Vlietstra R E, Kronmal R A, Frye R L, Seth A K, Tristani F E, Killip T
Arteriosclerosis. 1982 May-Jun;2(3):208-15. doi: 10.1161/01.atv.2.3.208.
This study was designed to test the relationship between each of nine risk variables and the extent and severity of coronary artery disease in 15,298 patients with coronary artery disease proven by arteriography who were enrolled in the Coronary Artery Surgery Study. The extent and severity of the disease were highly significantly (p less than 0.001), but modestly, correlated with age, sex, cholesterol levels, history of diabetes, and history of hypertension. Interestingly, no positive correlation (indeed, in some subgroups, a negative correlation) occurred between the arteriographic measures of disease and the cigarette smoking history (ever or never, number of pack-years of smoking, duration of cigarette smoking, and peak daily cigarette consumption). These results suggest that the risk factors for presence of disease may differ from those influencing angiographic extent and severity.
本研究旨在测试9个风险变量中的每一个与15298例经动脉造影证实患有冠状动脉疾病并参加冠状动脉手术研究的患者的冠状动脉疾病范围及严重程度之间的关系。疾病的范围和严重程度与年龄、性别、胆固醇水平、糖尿病史和高血压史高度显著相关（p小于0.001），但相关性较弱。有趣的是，疾病的动脉造影测量结果与吸烟史（曾经吸烟或从不吸烟、吸烟包年数、吸烟持续时间以及每日吸烟峰值）之间没有正相关（实际上，在一些亚组中存在负相关）。这些结果表明，疾病存在的风险因素可能与影响血管造影范围和严重程度的因素不同。
