通过常规冠状动脉造影评估吸烟与冠状动脉疾病的关系。
Smoking and coronary artery disease assessed by routine coronary arteriography.
作者信息
Ramsdale D R, Faragher E B, Bray C L, Bennett D H, Ward C, Beton D C
出版信息
Br Med J (Clin Res Ed). 1985 Jan 19;290(6463):197-200. doi: 10.1136/bmj.290.6463.197.
Abstract
The association between extent and duration of smoking habit and severity of coronary atheroma was examined in 387 patients undergoing routine coronary ateriography before valve replacement surgery. Total number of cigarettes smoked in life correlated significantly with severity of coronary artery disease (p less than 0.001) and number of coronary arteries with stenoses of 50% or more (p less than 0.001). Severity of coronary artery disease in current smokers was similar to that in former smokers. Multiple regression analysis showed diastolic blood pressure, cigarette consumption, age, ratio of total cholesterol to high density lipoprotein cholesterol, and history of angina to be the important predictors of severity of coronary artery disease. An estimate of the number of cigarettes smoked in life can be useful in identifying patients with coronary artery disease if used in conjunction with data on other important risk factors.
摘要
在387例接受瓣膜置换手术前行常规冠状动脉造影的患者中，研究了吸烟习惯的程度和持续时间与冠状动脉粥样硬化严重程度之间的关联。终生吸烟总数与冠状动脉疾病的严重程度显著相关（p<0.001），与狭窄50%或以上的冠状动脉数量也显著相关（p<0.001）。当前吸烟者的冠状动脉疾病严重程度与既往吸烟者相似。多元回归分析显示，舒张压、吸烟量、年龄、总胆固醇与高密度脂蛋白胆固醇之比以及心绞痛病史是冠状动脉疾病严重程度的重要预测因素。如果将终生吸烟量的估计值与其他重要危险因素的数据结合使用，对于识别冠状动脉疾病患者可能会有帮助。
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