20α-羟类固醇脱氢酶在非淋巴细胞造血细胞系中的表达
Expression of 20 alpha-hydroxysteroid dehydrogenase in nonlymphoid hemopoietic cell lines.
作者信息
Garland J M, Lanotte M, Dexter T M
出版信息
Eur J Immunol. 1982 Apr;12(4):332-6. doi: 10.1002/eji.1830120414.
PMID:6980122
Abstract
Expression of 20 alpha-hydroxysteroid dehydrogenase (20 alpha-SDH), a putative T cell marker, has been examined in a number of nonlymphoid hemopoietic cell lines. Both promyelocytic and stromal bone marrow lines expressed significant 20 alpha-SDH activity which was not correlated with virus infection or growth rate. 20 alpha-SDH therefore is not a unique marker for T cells in hemopoietic tissues. This result is discussed in relationship to the action of the newly proposed interleukin 3.
摘要
一种假定的T细胞标志物——20α-羟基类固醇脱氢酶（20α-SDH），已在多种非淋巴细胞造血细胞系中进行了检测。早幼粒细胞系和骨髓基质系均表达出显著的20α-SDH活性，且该活性与病毒感染或生长速率无关。因此，20α-SDH并非造血组织中T细胞的独特标志物。结合新提出的白细胞介素3的作用对该结果进行了讨论。
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Expression of 20 alpha-hydroxysteroid dehydrogenase in nonlymphoid hemopoietic cell lines.20α-羟类固醇脱氢酶在非淋巴细胞造血细胞系中的表达
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