Someya S, Shomura T, Murata S
Jpn J Antibiot. 1982 Mar;35(3):761-5.
The tissue distribution of 9, 3"-diacetylmidecamycin (MOM) was studied in the pregnant rats and in the rats following repeated administration. After oral administration of MOM (200 mg/kg) in the pregnant rats, the levels in the placenta and in the uterus were 2-3 times higher than that in the blood, however the levels in the amniotic fluid and in the fetus were 1/10-1/20 of the blood levels. After the third administration of MOM in the first day (30 mg/kg p.o./dose, 3 times/day, 4-hour interval), the levels in the liver, kidney, lungs, spleen, salivary glands and thymus were 1.5-12 times higher than that in the blood; the level in the muscle was almost equal to that in the blood; and the levels in the brain were 1/3-1/10 of the blood level. The tissue distribution patterns after repeated administrations were found to be similar to those of the first day administrations.
研究了9, 3”-二乙酰麦迪霉素（MOM）在妊娠大鼠及反复给药大鼠中的组织分布情况。给妊娠大鼠口服MOM（200mg/kg）后，胎盘和子宫中的药物水平比血液中的高2 - 3倍，然而羊水中和胎儿体内的药物水平是血液水平的1/10 - 1/20。在第一天第三次给药MOM（30mg/kg口服/剂量，每天3次，间隔4小时）后，肝脏、肾脏、肺、脾脏、唾液腺和胸腺中的药物水平比血液中的高1.5 - 12倍；肌肉中的药物水平与血液中的几乎相等；大脑中的药物水平是血液水平的1/3 - 1/10。发现反复给药后的组织分布模式与第一天给药后的相似。
