新型大环内酯类抗生素醋酸麦迪霉素（美欧卡霉素）的毒理学研究。第四部分-3。美欧卡霉素代谢产物的毒性：Mb1对大鼠的亚急性毒性。
Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-3. Toxicity of metabolites of miocamycin: subacute toxicity of Mb1 in rats.
作者信息
Yokota M, Takeda U, Odaki M, Sasaki H, Niizato T, Kawaoto H, Watanabe H, Ishiwatari N, Hayasaka H, Koeda T
出版信息
Jpn J Antibiot. 1984 Aug;37(8):1494-506.
Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic and is metabolized into 4 main metabolites of Mb1, Mb2, Mb6 and Mb12. In the previous study, LD0 values of Mb1 were estimated more than 5,000 mg/kg in male and female rats as Mb1 did not exhibited any lethal toxicity even at the maximum physically applicable dose of 5,000 mg/kg. The object of this study was to examine subacute toxicity in male and female rats after repeated p.o. administration of Mb1 for 5 weeks at a daily dosage of 125, 250, 500 and 1,000 mg/kg. It is concluded that no manifest toxicity was observed in this subacute toxicity study on Mb1 in rats.
麦白霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种大环内酯类抗生素，可代谢为4种主要代谢产物Mb1、Mb2、Mb6和Mb12。在先前的研究中，Mb1在雄性和雌性大鼠中的LD0值估计超过5000mg/kg，因为即使在最大实际适用剂量5000mg/kg时，Mb1也未表现出任何致死毒性。本研究的目的是检查雄性和雌性大鼠在每天口服125、250、500和1000mg/kg剂量的Mb1 5周后的亚急性毒性。得出的结论是，在这项关于大鼠Mb1的亚急性毒性研究中未观察到明显毒性。
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