全科医疗患者的地高辛依从性
Digoxin compliance in patients from general practice.
作者信息
Johnston G D, McDevitt D G
出版信息
Br J Clin Pharmacol. 1978 Oct;6(4):339-43. doi: 10.1111/j.1365-2125.1978.tb00861.x.
Abstract
- Compliance with digoxin therapy has been assessed in a group of fifty patients receiving the drug in general practice but not attending hospital. 2. Compliance was estimated by comparing plasma digoxin concentrations before and after a 10 day period of measured digoxin consumption and by tablet counting. 3. Twelve patients had plasma concentrations which increased by more than 0.4 ng/ml during monitored intake and eight other patients took less than 80% of their tablets. These twenty patients were considered non-compliant. 4. A further three patients in whom plasma digoxin levels were zero when first seen but increased substantially during the run-in period were also adjudged non-compliant. 5. Non-compliance with prescribed digoxin dosage occurred, therefore, in 46% of the patients studied.
摘要
- 在一组50名接受地高辛治疗但未住院的患者中评估了地高辛治疗的依从性。2. 通过比较10天测量的地高辛消耗量前后的血浆地高辛浓度以及通过片剂计数来估计依从性。3. 12名患者在监测摄入期间血浆浓度增加超过0.4 ng/ml，另外8名患者服用的片剂少于其应服量的80%。这20名患者被视为不依从。4. 另外3名患者首次就诊时血浆地高辛水平为零，但在磨合期内大幅升高，也被判定为不依从。5. 因此，在所研究的患者中，46%出现了未遵医嘱服用地高辛剂量的情况。
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