Spouge J L, Easterbrook-Smith S B
Mol Immunol. 1982 Feb;19(2):253-6. doi: 10.1016/0161-5890(82)90338-8.
An error in a previous article [Cohen S. (1968) J. Immun. 100, 407-413] was discovered which invalidates it as evidence that IgG immune complexes activate the classical complement pathway by an interaction involving pairs of antibody molecules, so-called doublet formation. The error concerns the correction to be made for the observed 8% residual activity of the modified antibody preparation used. When appropriate correction factors are applied, the data are found not to be consistent with the hypothesis of doublet formation. The analysis presented here has no bearing on the original article's experimental techniques, nor on its demonstration of co-operation between IgG molecules during complement fixation.
在之前的一篇文章[科恩 S.（1968 年）《免疫学杂志》100 卷，407 - 413 页]中发现了一个错误，这使得该文章不能作为 IgG 免疫复合物通过涉及抗体分子对的相互作用（即所谓的双联体形成）激活经典补体途径的证据。该错误涉及对所使用的修饰抗体制剂观察到的 8%残余活性应进行的校正。当应用适当的校正因子时，发现数据与双联体形成的假设不一致。此处给出的分析与原文章的实验技术无关，也与原文章关于 IgG 分子在补体固定过程中的协同作用的论证无关。
