Cox R A, Pope R M, Stevens D A
Am Rev Respir Dis. 1982 Sep;126(3):439-43. doi: 10.1164/arrd.1982.126.3.439.
Circulating immune complexes were quantitated by Clq-binding assays of serum from 73 patients with active coccidioidomycosis, 5 patients with inactive disease, and 34 healthy subjects. Immune complexes were detected in serums of 8 (44%) of 18 patients with active pulmonary disease only and 22 (40%) of 55 patients with active disseminated disease. Results in none of 5 patients with inactive disease and in only 2 (9%) of 34 healthy subjects were positive by the Clq-binding assay. Immune complex levels did not differ in patients with pulmonary disease versus those with disseminated disease. However, immune complexes did correlate with disease involvement. Of 57 patients with coccidioidomycosis involving a single organ system (pulmonary or extrapulmonary), 19 (33%) had immune complexes compared with 6 (67%) of 9 patients with disease involving 2 organ systems, and 5 (71%) of 7 patients with disease of 3 or more organ systems. Immune complex levels correlated with serum IgG, but did not correlate with serum complement-fixing antibody titers to coccidioidin. Rather, the correlation curve between immune complexes and complement-fixing antibody titers yielded a bell-shaped distribution. This distribution pattern suggests that changes in antibody concentration may have effected the size and lattice of immune complexes, resulting in altered detection and/or clearance from the bloodstream.
通过对73例活动性球孢子菌病患者、5例非活动性疾病患者和34名健康受试者的血清进行Clq结合试验，对循环免疫复合物进行定量分析。仅在18例活动性肺部疾病患者中的8例（44%）血清以及55例活动性播散性疾病患者中的22例（40%）血清中检测到免疫复合物。5例非活动性疾病患者中无一例通过Clq结合试验呈阳性，34名健康受试者中仅有2例（9%）呈阳性。肺部疾病患者与播散性疾病患者的免疫复合物水平无差异。然而，免疫复合物确实与疾病累及情况相关。在57例累及单一器官系统（肺部或肺外）的球孢子菌病患者中，19例（33%）有免疫复合物，而在9例累及2个器官系统的疾病患者中有6例（67%）有免疫复合物，在7例累及3个或更多器官系统的疾病患者中有5例（71%）有免疫复合物。免疫复合物水平与血清IgG相关，但与血清抗球孢子菌素补体结合抗体滴度无关。相反，免疫复合物与补体结合抗体滴度之间的相关曲线呈钟形分布。这种分布模式表明抗体浓度的变化可能影响了免疫复合物的大小和晶格，导致其在血液中的检测和/或清除发生改变。
