Ia + B细胞杂交瘤向H - 2限制性T细胞杂交瘤的抗原呈递。
Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.
作者信息
Kappler J, White J, Wegmann D, Mustain E, Marrack P
出版信息
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3604-7. doi: 10.1073/pnas.79.11.3604.
Abstract
The Ia+, H-2d BALB/c lymphoma cell line L10.A 2J was fused to T cell-depleted spleen cells from mouse strains bearing other H-2 haplotypes. A portion of the selected hybrids expressed Ia antigens of the normal spleen cell partner in the fusion as evidenced by their presentation of various antigens to a set of antigen-specific I-region-restricted T cell hybridomas. Three cloned hybrids were studied in detail. Antigen presentation was shown to be inhibited specifically by monoclonal anti-Ia antibodies. Both I-A and I-E molecules were expressed, including in the one case examined hybrid I-A and I-E molecules between the H-2d and H-2b haplotypes. These Ia+ B cell hybridomas provide a useful set of tools for studying the role of I-region-encoded molecules in antigen presentation to T cells.
摘要
将Ia +、H - 2d BALB/c淋巴瘤细胞系L10.A 2J与来自携带其他H - 2单倍型的小鼠品系的T细胞耗尽的脾细胞进行融合。所选杂种细胞的一部分表达了融合中正常脾细胞伙伴的Ia抗原，这可通过它们将各种抗原呈递给一组抗原特异性I区限制性T细胞杂交瘤来证明。对三个克隆的杂种细胞进行了详细研究。抗原呈递被证明可被单克隆抗Ia抗体特异性抑制。I - A和I - E分子均有表达，在所研究的一个案例中，还包括H - 2d和H - 2b单倍型之间的杂种I - A和I - E分子。这些Ia + B细胞杂交瘤为研究I区编码分子在向T细胞呈递抗原中的作用提供了一组有用的工具。
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