来自兔子的肿瘤坏死因子。II. 单核细胞的产生。
Tumour-necrosis factor from the rabbit. II. Production by monocytes.
作者信息
Matthews N
出版信息
Br J Cancer. 1978 Aug;38(2):310-5. doi: 10.1038/bjc.1978.203.
Abstract
Mononuclear cells from normal rabbit blood were cytotoxic to a number of cell lines in vitro. The cytotoxic cells were contained in the monocyte-enriched fraction adherent to plastic. Supernatants of the monocyte-enriched fraction had the same cytotoxic specificity as the parent cells. The cytotoxic factor precipitated in 50% saturated ammonium sulphate solution and on gel filtration was heterogeneous with a mol.-wt. range of 30--50,000 u. On the basis of specificity and molecular characteristics, this cytotoxic factor closely resembles rabbit tumour-necrosis factor (TNF) suggesting that TNF or a closely related factor is a normal product of mononuclear phagocytes.
摘要
正常兔血中的单核细胞在体外对多种细胞系具有细胞毒性。细胞毒性细胞存在于附着于塑料的富含单核细胞的部分中。富含单核细胞部分的上清液与亲代细胞具有相同的细胞毒性特异性。细胞毒性因子在50%饱和硫酸铵溶液中沉淀，经凝胶过滤后分子量不均一，范围为30 - 50,000道尔顿。基于特异性和分子特征，这种细胞毒性因子与兔肿瘤坏死因子（TNF）非常相似，表明TNF或密切相关的因子是单核吞噬细胞的正常产物。
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