Ritchie J L, Larsson S, Israelson A, Schnell P O, Holmgren A, Williams D L, Thorell J I
Eur J Nucl Med. 1982;7(6):254-9. doi: 10.1007/BF00251476.
A standard heart phantom (University of Iowa design), including discrete myocardial walls, a central blood pool, and a 24-cc transmural "cold" defect, was studied with both planar and transverse tomographic imaging. The heart phantom was filled with 201T1 and placed within a cylindrical tank containing water and 201T1 to simulate nonmyocardial background activity from the thorax. The tomographic imaging system used was a commercially available, rotating, large field-of-view gamma camera. Image reconstruction from 64 sampling angles was performed in a nuclear medicine minicomputer system. The percentage activity in the region of the defect (actual activity of 0) contrasted to the normal wall was compared between planar and 1.25-cm transaxial tomographic slices. Defect activity fell to between 65% and 85% of that of the opposing normal wall in planar images, whereas it fell to between 26% and 49% of that of the normal wall in the tomographic images. In most cases, tomographic defect activity was half or less than that in the planar image. The geographic extent of the defect was seen in an appropriate number of tomographic slices; i.e., the geographic 3.2-cm defect length was predominantly seen in three 1.25-cm transverse slices. We conclude that camera-based tomographic systems show promise for improved 201T1 myocardial defect detection and quantitation over conventional planar images.
使用平面成像和横向断层成像对一个标准心脏模型（爱荷华大学设计）进行了研究，该模型包括离散的心肌壁、中央血池和一个24立方厘米的透壁“冷”缺损。心脏模型充满201铊，并放置在一个装有水和201铊的圆柱形水箱中，以模拟来自胸部的非心肌本底活性。所使用的断层成像系统是一台商用的、旋转的、大视野伽马相机。在核医学微型计算机系统中从64个采样角度进行图像重建。比较了平面图像和1.25厘米轴向断层切片中缺损区域（实际活性为0）与正常壁的活性百分比。在平面图像中，缺损活性降至相对正常壁活性的65%至85%之间，而在断层图像中，其降至正常壁活性的26%至49%之间。在大多数情况下，断层缺损活性是平面图像中活性的一半或更低。在适当数量的断层切片中可以看到缺损的范围；即，3.2厘米长的缺损主要在三个1.25厘米的横向切片中可见。我们得出结论，基于相机的断层成像系统在检测和定量201铊心肌缺损方面比传统平面图像更有前景。
