Increased mortality in the siblings and offspring of Pi type MS and MZ men from Saskatchewan. Mortality and Pi type.

alpha 1-Antitrypsin phenotypes were determined in 1,395 male Saskatchewan grain buyers. These included 1,254 type M, 80 MS, 35 MZ and 26 which were untyped or other rare phenotypes. Sibling and offspring of the MS men had a significantly greater number of deaths (p less than 0.01). Offspring of MZ men also had an increased number of deaths. These appeared to occur in all age except in those 2-17 years of age. This finding raises questions about the role of both the S and Z alleles.