在一项社区调查中，Pi MZ表型与报告的银屑病患病率增加。

Pi MZ phenotype and an increased prevalence of reported psoriasis in a community survey.

作者信息

Horne S L, Junk G J, Cockcroft D W, Lovegrove A, Dosman J A

出版信息

Hum Hered. 1986;36(4):266-8. doi: 10.1159/000153641.

Abstract

In a community survey of 953 adults we identified 40 who reported having had psoriasis. Eight of these cases were subsequently documented from physicians' records. alpha 1-Antitrypsin (alpha 1-AT) phenotyping identified 35 MZ individuals, 4 (11.4%) of whom reported psoriasis. Among the 918 non-MZ individuals 36 (3.9%) reported psoriasis, yielding a relative incidence of 3.2 (p less than 0.05). This is consistent with previous reports suggesting an association between moderate alpha 1-AT deficiency and psoriasis.

摘要

在一项针对953名成年人的社区调查中，我们确定有40人报告曾患银屑病。其中8例随后从医生记录中得到证实。α1-抗胰蛋白酶（α1-AT）表型分析确定了35名MZ个体，其中4人（11.4%）报告患有银屑病。在918名非MZ个体中，36人（3.9%）报告患有银屑病，相对发病率为3.2（p<0.05）。这与之前的报告一致，表明中度α1-AT缺乏与银屑病之间存在关联。