Karande A A, Gulwani B, Advani S H, Gangal S G
Neoplasma. 1982;29(2):149-59.
Circulating T gamma and T mu cells enumerated in the peripheral blood of 51 untreated Hodgkin's disease (HD) patients and 66 treated HD patients tested after few months to more than 3 years of remission, brought about by radiation and/or chemotherapy. 53 age matched normal healthy individuals were studied as controls. Untreated HD patients showed significant increase in T gamma cells (p less than 0.001) and decrease in T mu cells (p less than 0.001) when compared to normal donors. The abnormal percentages of T cell subsets did not correlate with the severity of the disease. A progressive partial restoration in the proportion of these two subsets of T lymphocytes was seen in the disease free condition. However, even after 3 years of remission the recovery was not equivalent to controls. There was no correlation between the recovery of T gamma and T mu cells with the modality of treatment.
对51例未经治疗的霍奇金病（HD）患者以及66例经放疗和/或化疗缓解数月至3年以上的HD患者外周血中循环Tγ细胞和Tμ细胞进行计数，并以53名年龄匹配的正常健康个体作为对照。与正常供体相比，未经治疗的HD患者Tγ细胞显著增加（p<0.001），Tμ细胞减少（p<0.001）。T细胞亚群的异常百分比与疾病严重程度无关。在无病状态下，这两个T淋巴细胞亚群的比例逐渐部分恢复。然而，即使缓解3年后，恢复情况仍与对照组不等同。Tγ细胞和Tμ细胞的恢复与治疗方式无关。
