Davies E G, Levinsky R J
Pediatr Res. 1982 Jul;16(7):573-8. doi: 10.1203/00006450-198207000-00018.
Eight children, four with combined immunodeficiencies and four with isolated T cell defects were treated with TPI, a crude calf thymic extract. Assessment of response was made on clinical grounds and by monitoring of immune function (T and B cell numbers, immunoglobulin levels, PHA response and delayed cutaneous reaction to Candida antigen). One child with severe combined immunodeficiency showed marked clinical improvement together with reconstitution of T cell numbers and, surprisingly, B cell numbers and immunoglobulin production. Two further children, one with a form of combined immunodeficiency and the other with a T cell defect and extensive cutaneous herpes simplex infection, showed benefit from therapy though in the latter we could not demonstrate that this was important in clearing the virus infection. None of the other children showed any consistent improvement either clinically or on testing. We found no evidence of toxicity, allergy or other adverse effects of therapy.
八名儿童接受了胸腺肽（TPI，一种粗制小牛胸腺提取物）治疗，其中四名患有联合免疫缺陷，另外四名患有单纯T细胞缺陷。通过临床观察以及监测免疫功能（T细胞和B细胞数量、免疫球蛋白水平、PHA反应和对念珠菌抗原的迟发性皮肤反应）来评估治疗反应。一名患有严重联合免疫缺陷的儿童临床症状显著改善，同时T细胞数量得到恢复，令人惊讶的是，B细胞数量和免疫球蛋白产生也得以恢复。另外两名儿童，一名患有某种形式的联合免疫缺陷，另一名患有T细胞缺陷并伴有广泛的皮肤单纯疱疹感染，治疗后病情有所好转，不过对于后者，我们无法证明这对清除病毒感染具有重要意义。其他儿童在临床或检测方面均未表现出任何持续的改善。我们未发现治疗存在毒性、过敏或其他不良反应的证据。
