T淋巴细胞增殖性疾病中T淋巴细胞的E受体表达

E receptor expression of T lymphocytes in T lymphoproliferative diseases.

作者信息

Jønsson V, Andersen B L, Brandrup F, Christensen B E, Rothenborg H W, Thomsen K

出版信息

Scand J Haematol. 1982 Apr;28(4):329-34. doi: 10.1111/j.1600-0609.1982.tb00534.x.

DOI:10.1111/j.1600-0609.1982.tb00534.x

Abstract

The lymphoid component of skin infiltrates from 6 cases of mycosis fungoides and 2 cases of T cell chronic lymphatic leukaemia consisted almost exclusively of T lymphocytes with abnormally high E receptor expression. Such T cells were also found to dominate the skin infiltrates from 10 patients with severe atopic dermatitis. Blood T lymphocyte counts from all types of patients were within the normal range, but even the blood T lymphocytes of the patients had a strong E receptor expression. The bone marrow in atopic dermatitis and in mycosis fungoides showed normal T cell counts with normal E receptor expression. Supported by basic lymphocyte-kinetic considerations it is likely that the skin in T lymphoproliferative diseases is characterized by an abnormal ability to home and/or to trap T lymphocytes with strong E receptor expression.

摘要

6例蕈样肉芽肿和2例T细胞慢性淋巴细胞白血病患者皮肤浸润的淋巴细胞成分几乎全部是E受体表达异常增高的T淋巴细胞。在10例重度特应性皮炎患者的皮肤浸润中也发现此类T细胞占主导。所有类型患者的血液T淋巴细胞计数均在正常范围内，但即便这些患者的血液T淋巴细胞也有很强的E受体表达。特应性皮炎和蕈样肉芽肿患者的骨髓显示T细胞计数正常，E受体表达也正常。基于基本的淋巴细胞动力学考虑，T淋巴细胞增殖性疾病患者的皮肤可能具有异常的归巢能力和/或捕获E受体表达强的T淋巴细胞的能力。