Simon M, Djawari D
Z Hautkr. 1982 Jun 15;57(12):879-83.
Various immunological parameters were studied in 49 patients suffering from recurrent herpes simplex and in 100 healthy sex- and age-matched individuals. The study included determination of immunoglobulins in serum, classification and PHA-stimulation of peripheral lymphocytes as well as testing different granulocyte functions in vitro. We found a moderately reduced number of T-lymphocytes in 20 patients and a strikingly decreased rate of PHA-induced lymphocyte transformation in 30 patients. A slight impairment of chemotactic activity and markedly reduced capacity of killing Candida albicans blastospores by granulocytes was also found. These results point to an immunological alteration in patients with recurrent herpes simplex.
对49例复发性单纯疱疹患者和100名年龄及性别匹配的健康个体的各种免疫学参数进行了研究。该研究包括血清免疫球蛋白的测定、外周淋巴细胞的分类和PHA刺激，以及体外不同粒细胞功能的检测。我们发现20例患者的T淋巴细胞数量适度减少，30例患者PHA诱导的淋巴细胞转化率显著降低。还发现粒细胞趋化活性略有受损，杀灭白色念珠菌芽生孢子的能力明显降低。这些结果表明复发性单纯疱疹患者存在免疫改变。
