Yoshimura K, Sato K, Uchida K, Oya H
Z Parasitenkd. 1982;67(2):217-26. doi: 10.1007/BF00928117.
BALB/c athymic nude and thymus-reconstituted nude mice and neonatally thymectomized BALB/c mice were infected with stage 3 larvae of Angiostrongylus cantonensis and the worm burdens of the mice were determined at various times after infection. When the nude and thymectomized mice were exposed to the parasite, some worms were found to migrate from the brain to lungs but died there without reaching maturity. This pulmonary arterial migration of the worms in the nude did not occur following thymic reconstitution. These data suggest that the inability of murine intracranial worms to migrate to the lungs is at least in part due to thymus-dependent mechanisms, and also that the failure of worm maturation in mouse lungs might be due to thymus-independent immune mechanisms and/or nonimmunological mechanisms.
将BALB/c无胸腺裸鼠、胸腺重建的裸鼠以及新生期胸腺切除的BALB/c小鼠感染广州管圆线虫的3期幼虫，并在感染后的不同时间测定小鼠体内的虫负荷。当裸鼠和胸腺切除的小鼠接触该寄生虫时，发现一些蠕虫从脑向肺迁移，但在那里死亡而未发育成熟。胸腺重建后，裸鼠体内蠕虫的这种肺动脉迁移未发生。这些数据表明，鼠颅内蠕虫无法迁移至肺至少部分归因于胸腺依赖性机制，并且鼠肺内蠕虫成熟失败可能归因于胸腺非依赖性免疫机制和/或非免疫机制。
