Lange R D, Jones J B
Am J Pediatr Hematol Oncol. 1982 Summer;4(2):223-9.
The cellular elements of the blood are normally maintained in a remarkable steady state. However, in human patients with cyclic neutropenia and in a putative animal model--canine cyclic hematopoiesis--the formed elements oscillate with constant regularity. The clocklike precision of the cycles implies a strong regulatory control failure. Since an understanding of the pathogenesis of these events could enhance our perception of normal and abnormal regulatory mechanisms, we have undertaken briefly to review current concepts regarding the possible etiologies of cyclic hematopoiesis.
血液中的细胞成分通常保持在一种显著的稳定状态。然而，在患有周期性中性粒细胞减少症的人类患者以及一种假定的动物模型——犬类周期性造血——中，血细胞成分会以恒定的规律振荡。这些周期的时钟般精确性意味着强大的调节控制出现故障。由于了解这些事件的发病机制可以增强我们对正常和异常调节机制的认识，我们简要回顾了当前关于周期性造血可能病因的概念。
