Borrajo E, Alpera R, Donat J, Escribano A, Colomer C, Plasencia A, López M J
An Esp Pediatr. 1982 May;16(5):369-76.
For a long time investigators have focused attention on the relationship between specific immunity and hormones. In the present paper, authors investigated on 26 children, 9 males and 17 females, from 9 months to 14 and 10/12 years old, with primary hypothyroidism. All patients were in substitutive treatment. The following studies were done to all the patients: serum IgG, IgA, IgM and complement. Blood lymphocyte counts, percentages of B and T lymphocytes, as well as the response of lymphocytes to PHA. Skin tests were also carried out: tuberculin, candidin and streptokinase-streptodornase. All results obtained in both, hypothyroid and control groups fell within the range of normal age-matched values for our laboratory, and by results of statistics studies carried out they were considered of little significance, except the percentage of circulating B lymphocytes that was lower in hypothyroid group (p less than or equal to 0.01).
长期以来，研究人员一直关注特异性免疫与激素之间的关系。在本文中，作者对26名年龄在9个月至14岁10/12个月的原发性甲状腺功能减退症患儿进行了研究，其中男性9名，女性17名。所有患者均接受替代治疗。对所有患者进行了以下研究：血清IgG、IgA、IgM和补体。血液淋巴细胞计数、B淋巴细胞和T淋巴细胞百分比，以及淋巴细胞对PHA的反应。还进行了皮肤试验：结核菌素、念珠菌素和链激酶-链道酶。甲状腺功能减退组和对照组获得的所有结果均在我们实验室年龄匹配的正常范围内，通过统计学研究结果，除循环B淋巴细胞百分比在甲状腺功能减退组较低（p小于或等于0.01）外，其他结果均无显著意义。
