Lagunas-Solar M C, Little F E, Moore H A
Int J Appl Radiat Isot. 1982 Aug;33(8):619-28. doi: 10.1016/0020-708x(82)90059-x.
The cyclotron production of the short-lived positron emitter 128Cs (3.62 min) from its longer-lived parent 128Ba (2.42 d), based upon the 133Cs(p, 6n) 128Ba leads to 128Cs reaction (Q = -43.98 MeV), has been studied. Cesium-128 has potential applications in positron tomography, particularly for imaging the myocardium and/or for the assessment of regional blood flow. Thick-target yields (mCi/muAh) and cross sections (mb) for 128Ba, 131Ba, 129Cs and 132Cs were measured in the 67-36 MeV proton-energy region. Cyclotron production of 128Ba-128Cs (transient equilibrium) was measured as 3.1 mCi/muAh at end of bombardment (EOB) with a 2.32 g cm-2 thick CsCl target with a proton entrance energy of 67 MeV and exit energy of 54 MeV. Target-radiochemistry using ion-exchange methods allow the preparation of a generator-type system from which high-radionuclidic purity, radiopharmaceutical quality, no-carrier-added 128Cs can be obtained for immediate administration. In addition, with proper radiochemical handling of the 128Ba-128Cs generator, no-carrier-added, high-purity 129Cs (32.35 h, 372 keV, 32%) can also be produced for use in research applications.
基于(^{133}Cs(p, 6n)^{128}Ba)反应（(Q = -43.98 MeV)），从其寿命较长的母体(^{128}Ba)（2.42天）通过回旋加速器生产短寿命正电子发射体(^{128}Cs)（3.62分钟）的过程已得到研究。铯 - 128在正电子断层扫描中具有潜在应用，特别是用于心肌成像和/或评估局部血流。在67 - 36 MeV质子能量区域测量了(^{128}Ba)、(^{131}Ba)、(^{129}Cs)和(^{132}Cs)的厚靶产额（(mCi/μAh)）和截面（(mb)）。在用质子入射能量为67 MeV、出射能量为54 MeV的(2.32 g cm^{-2})厚的(CsCl)靶进行轰击结束时（EOB），测量到回旋加速器生产(^{128}Ba - ^{128}Cs)（瞬态平衡）的产额为3.1 (mCi/μAh)。采用离子交换方法的靶放射化学可制备一种发生器型系统，从中可获得高放射性核素纯度、放射性药物质量、无载体添加的(^{128}Cs)以便立即给药。此外，通过对(^{128}Ba - ^{128}Cs)发生器进行适当的放射化学处理，还可生产无载体添加、高纯度的(^{129}Cs)（32.35小时，372 keV，32%）用于研究应用。
