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Cyclotron production of carrier-free 66Ga as a positron emitting label of albumin colloids for clinical use.

作者信息

Goethals P, Coene M, Slegers G, Agon P, Deman J, Schelstraete K

机构信息

Institute for Nuclear Sciences, Rijksuniversiteit Gent, Belgium.

出版信息

Eur J Nucl Med. 1988;14(3):152-4. doi: 10.1007/BF00293540.

DOI:10.1007/BF00293540
PMID:3261243
Abstract

A method for producing carrier free 66Ga (T1/2:9.4 h; beta +) by 4He bombardment of natural copper targets is presented. 66Ga is formed by means of the 63Cu (4He, n) 66Ga reaction. Production yields are given in the 17.5 to 8 MeV 4He energy range. Chemical purification of 66Ga from the copper target is described. The only radionuclidic impurity found in the final product was 67Ga. Albumin colloids from commercially available kits designed for use with 99mTc could easily be labeled with 66Ga and employed for studies of the lymphatic system by positron emission tomography.

摘要

相似文献

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本文引用的文献

1
Stable labelling of serum albumin microspheres with gallium-68.
Int J Rad Appl Instrum A. 1986;37(4):360-1. doi: 10.1016/0883-2889(86)90128-0.
2
Labeling of tin-soaked albumin microspheres with 68Ga.
J Nucl Med. 1976 Jan;17(1):57-60.
3
Gallium-68 labeling of albumin and albumin microspheres.
J Nucl Med. 1979 May;20(5):428-33.
用寿命更长的正电子放射性核素进行放射免疫成像：潜力与挑战。
Bioconjug Chem. 2009 May 20;20(5):825-41. doi: 10.1021/bc800299f.
4
Production of carrier-free 66Ga and labeling of antimyosin antibody for positron imaging of acute myocardial infarction.
Eur J Nucl Med. 1990;16(4-6):237-40. doi: 10.1007/BF00842774.