Engel J, Kuhl D E, Phelps M E
Science. 1982 Oct 1;218(4567):64-6. doi: 10.1126/science.6981843.
Ictal patterns of local cerebral metabolic rate have been studied in epileptic patients by positron computed tomography with 18F-labeled 2-fluoro-2-deoxy-D-glucose. Partial seizures were associated with activation of anatomic structures unique to each patient studied. Ictal increases and decreases in local cerebral metabolism were observed. Scans performed during generalized convulsions induced by electroshock demonstrated a diffuse ictal increase and postictal decrease in cerebral metabolism. Petit mal absences were associated with a diffuse increase in cerebral metabolic rate. The ictal fluorodeoxyglucose patterns obtained from patients do not resemble autoradiographic patterns obtained from common experimental animal models of epilepsy.
通过使用18F标记的2-氟-2-脱氧-D-葡萄糖的正电子计算机断层扫描技术，对癫痫患者局部脑代谢率的发作期模式进行了研究。部分性癫痫发作与每个研究患者特有的解剖结构激活有关。观察到局部脑代谢在发作期增加和减少。在电击诱发的全身性惊厥期间进行的扫描显示，脑代谢在发作期弥漫性增加，发作后期减少。失神小发作与脑代谢率的弥漫性增加有关。从患者获得的发作期氟脱氧葡萄糖模式与从常见癫痫实验动物模型获得的放射自显影模式不同。
