Schulte-Sasse U, Hess W, Tarnow J
Br J Anaesth. 1982 Oct;54(10):1053-8. doi: 10.1093/bja/54.10.1053.
The cardiovascular effects of midazolam 0.2 mg kg-1 i.v. were studied during the induction of anaesthesia in 16 premedicated patients subjected to cardiac surgery. In eight patients with coronary artery disease in whom global resting left ventricular function was normal the haemodynamic changes were small and observations on arterial pressure, cardiac index, stroke index, cardiac filling pressures, systemic and pulmonary vascular resistance appeared to parallel those accompanying deep sleep in healthy volunteers. In eight patients with valvular heart disease and haemodynamic evidence of moderately impaired cardiac performance, pump function during induction with midazolam was maintained, probably as a result of the tendency towards a decrease in systemic vascular resistance. Midazolam appears to be a valuable alternative to conventional induction agents without adverse effects on the cardiovascular system.
在16例接受心脏手术且已进行术前用药的患者麻醉诱导期间，研究了静脉注射0.2mg/kg咪达唑仑的心血管效应。在8例静息时左心室整体功能正常的冠心病患者中，血流动力学变化较小，动脉压、心脏指数、每搏指数、心脏充盈压、体循环和肺血管阻力的观察结果似乎与健康志愿者深度睡眠时的情况相似。在8例有瓣膜性心脏病且有心脏功能中度受损血流动力学证据的患者中，咪达唑仑诱导期间的泵功能得以维持，这可能是由于体循环血管阻力有降低趋势的结果。咪达唑仑似乎是传统诱导药物的一种有价值的替代药物，对心血管系统无不良影响。
