Saleh A M, Pheasant A E, Blair J A, Allan R N, Walters J
Br J Cancer. 1982 Sep;46(3):346-53. doi: 10.1038/bjc.1982.210.
The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding included the unchanged compound, other folates and a number of breakdown products, such as p-acetamidobenzoyl-L-glutamate and p-acetamidobenzoate. This confirms the existence of a folate catabolic pathway in man. Patients with malignant disease excreted less of the dose in urine, incorporated more into the reduced folate pool, and showed decreased catabolism of folate, when compared to controls. 10-Formylfolate was excreted largely unchanged, and appears not to be reduced by man. Also 10-formylfolate interfered with the reduction of folic acid given simultaneously.
对[2-¹⁴C]+[3',5',7,9-³H]叶酸和[2-¹⁴C]+[3',5',7,9-³H]10-甲酰叶酸在住院患者中的代谢情况进行了研究。叶酸摄入后在尿液中检测到的代谢产物包括未变化的化合物、其他叶酸以及一些分解产物，如对乙酰氨基苯甲酰-L-谷氨酸和对乙酰氨基苯甲酸。这证实了人体中叶酸分解代谢途径的存在。与对照组相比，患有恶性疾病的患者尿液中排出的剂量较少，更多地纳入还原型叶酸池，并且叶酸分解代谢减少。10-甲酰叶酸大部分原样排出，似乎不会被人体还原。此外，10-甲酰叶酸会干扰同时给予的叶酸的还原过程。
