Arango M, Yarzábal L
Mycopathologia. 1982 Aug 20;79(2):115-23. doi: 10.1007/BF00468089.
Various aspects of T and B cell mediated immunity were investigated in 20 well documented cases of active (10) or inactive (10) paracoccidioidomycosis (Pcm), as well as in 8 healthy individuals living in the endemic area of the disease. The results confirm previous reports that active Pcm produces diverse grades of depression of T cell mediated immunity. Such T cell dysfunction is not associated with a reduction in the number of peripheral E rosette-forming cells, and the immunodepression is reversed by chemotherapy. Sera from Pcm (active or inactive) patients have significantly increased levels of total IgE, but the actual proportion of IgE antibodies against P. brasiliensis was very low (0.4-0.6%). The highest levels of total IgE were found in active patients with disease-related immune depression, suggesting that T cell dysfunction might contribute to the excessive IgE production.
在20例有充分记录的活动性（10例）或非活动性（10例）副球孢子菌病（Pcm）患者以及8名生活在该病流行区的健康个体中，对T细胞和B细胞介导的免疫的各个方面进行了研究。结果证实了先前的报道，即活动性Pcm会导致不同程度的T细胞介导的免疫抑制。这种T细胞功能障碍与外周E花环形成细胞数量的减少无关，并且免疫抑制可通过化疗逆转。Pcm（活动性或非活动性）患者的血清中总IgE水平显著升高，但针对巴西副球孢子菌的IgE抗体的实际比例非常低（0.4 - 0.6%）。在患有与疾病相关免疫抑制的活动性患者中发现了最高水平的总IgE，这表明T细胞功能障碍可能导致IgE过度产生。
