Boyd J E, Robertson M D, Davis J M
Am J Ind Med. 1982;3(2):201-8. doi: 10.1002/ajim.4700030211.
Sera from 2421 coalminers, representing all the radiological categories of pneumoconiosis, and from 260 healthy blood donors, as controls, were examined for antinuclear factor and rheumatoid factor. Antinuclear factors were present in 21.5% of sera from the controls and in 23.1% from the coalminers' group. Rheumatoid factor was present in 5.3% of coalminers and as expected occurred particularly in the few men with progressive massive fibrosis who also had rheumatoid disease. The combined prevalence of both factors showed an increase with age at all disease levels and a significant association with pneumoconiosis category only in men older than 60 years. This study provides no evidence that autoantibodies are likely to be of value in detecting men predisposed to the development of massive fibrosis other than those with rheumatoid disease.
对2421名代表尘肺病所有放射学类别的煤矿工人的血清以及260名作为对照的健康献血者的血清进行了抗核因子和类风湿因子检测。对照血清中21.5%存在抗核因子，煤矿工人组血清中23.1%存在抗核因子。类风湿因子在5.3%的煤矿工人中存在，正如预期的那样，尤其在少数患有进行性大块纤维化且同时患有类风湿病的男性中出现。在所有疾病水平上，这两种因子的合并患病率均随年龄增加，且仅在60岁以上男性中与尘肺病类别存在显著关联。这项研究没有提供证据表明自身抗体除了对患有类风湿病的男性外，在检测易发生大块纤维化的男性方面可能有价值。
