Soutar C A, Turner-Warwick M, Parkes W R
Br Med J. 1974 Jul 20;3(5924):145-7. doi: 10.1136/bmj.3.5924.145.
Circulating antinuclear antibody and rheumatoid factor have been measured in 109 coal miners with pneumoconiosis whose chest radiograph showed a range of abnormalities varying from simple pneumoconiosis of mild degree to advanced progressive massive fibrosis.At a screening dilution of 1/10 the overall incidence of antinuclear antibody was 17%. In almost half of the positive cases the titre was 1/40 or greater.The prevalence of antinuclear antibody was lowest in those with simple pneumoconiosis (9%) and highest in those with category C progressive massive fibrosis (27%). A similar but less striking trend was seen with rheumatoid factor, ranging from 6% in simple pneumoconiosis to 18% in category C progressive massive fibrosis. The trend of increasing frequency of autoantibodies with advancing radiographic category was most marked when the frequencies of antinuclear antibody and rheumatoid factor were combined. These autoantibodies were found in 13% of the miners with simple pneumoconiosis and 45% of those with category C progressive massive fibrosis (P for the trend=0.01).
对109名尘肺病煤矿工人进行了循环抗核抗体和类风湿因子检测，这些工人的胸部X光片显示出一系列异常，从轻度单纯尘肺病到晚期进行性大块纤维化不等。在1/10的筛查稀释度下，抗核抗体的总体发生率为17%。在几乎一半的阳性病例中，滴度为1/40或更高。抗核抗体的患病率在单纯尘肺病患者中最低（9%），在C类进行性大块纤维化患者中最高（27%）。类风湿因子也有类似但不太明显的趋势，从单纯尘肺病中的6%到C类进行性大块纤维化中的18%。当抗核抗体和类风湿因子的频率合并时，随着放射学分类的进展，自身抗体频率增加的趋势最为明显。在单纯尘肺病矿工中，13%发现了这些自身抗体，在C类进行性大块纤维化矿工中，45%发现了这些自身抗体（趋势P值=0.01）。
